I have armor and IF, I just shrug most of them off. Well, that applies to arrows mostly, heavy crossbows and throwing still hurt like hell. But getting hit by heavy crossbow twice is kind of rare, throwers are a pain, but mostly someone else will look like an easy kill for them and you can rush them while they look the other way.
It's not really a problem getting many kills as pure 2h for me, but most rounds I die. I have no problem with that, though, you just wait a bit in cover, rush at the right moment and take as many people down with you as you can.