Man I don't know what it is about it, but switching to inverse a few weeks ago when I started playing crpg, after having played standard in sp since a while ago, it's like a whole new world was unlocked. I can't even fathom going back now. I guess I can't call it intuitive, since I went with the other way first, but if it was once counter-intuitive, it quickly became and is very intuitive now.
But I like blocking not being inverted at the same time. Allows for more position switches and flowing opportunities, mouse handling wise. Except my hands are stupid and won't listen to me so I can't often take advantage of these opportunities.