If you get 200+ ping consistently, don't bother with melee. 150-180, sure, you'll have a disadvantage, but it's playable. I'm an idiot and I play melee on NA with 230 ping. It's frustrating as hell.
You have to have your block up well and truly before your enemy's attack animation begins for blocks to actually work, so it becomes guesswork.
You can land kicks, but even if you attack directly after your kick has landed, the attack will be delayed and your enemy won't be stunned anymore by the time you start swinging.
The positional lag, oh boy. It completely fucks footwork and judging weapon reach. I am constantly swinging through people and getting hit by people that are attacking the air 2 meters in front of me. All you can really do is s key with a high damage, long reach weapon and hope your opponent is stupid enough to fall for a tactic that has been around since the first week of multi player warband. Feint spam might get you the odd kill too, but it's generally too risky as you can't cancel out of it in time to block an enemy's attack that's interrupting your feint routine.
Just forgot about the wireless; even I have a wired connection in the middle of nowhere on some shitty island aka Australia