The only real priority is getting enough strength to use the weapon you want, really.
A good starter build for aspiring two-hander heroes is 21 strength and 18 agility. 7 Power Strike, 6 Athletics, 6 Ironflesh, 4 Weapon Master, all two-hander weapon proficiency points. Enough strength to use any two-handed weapon and still have some decent mobility.
It's a good build to get a feel for the style and give an idea on what weapons you want to use in the future.