Between D&D 4E, Pathfinder, Dark Heresy (started a Daemonhunters/now Grey Knights army based on that group), Call of Cthulhu, and Shadowrun, I have a group almost every night of the week currently. I'll drop some eventually, but it's fun for now. It's nice having a store nearby with an owner that's also a good GM and event organizer.
I've never played in an online group. It seems very odd and detached compared to a group sitting around a table, though with a good program and vent it could be ok. I haven't played many systems beyond d20 and percentiles. I'll look into some of the ones posted here.
For 40K I've got about 2000 points of Grey Knights (or will come april anyway). For WHFB I've got probably a little over 3000 points of Ogres and 1000 points of Bretonnians (inspired by all my time playing M&B actually). I I've been playing a lot of World of Tanks in the past week, and that inspired me today to go digging for my Flames of War army that I bought and barely used a few years ago. Time to finish my Tiger platoon!