Quick spoiler that might as well not be a spoiler because it's bullshit but maybe you'll want to skip this post if you really want to keep the run blind.
Darkest Dungeon's difficulty curve is bad. The jump from novice to veteran dungeons isn't too bad, it's mostly just slightly tougher base enemies and a few new ones who are basically just beefier versions of what you've fought before. Stacking damage is viable and feels recommended because some of those new enemies have very large health pools. Then you'll get up to champion (level 5) dungeons and all of a sudden enemy critical hit and dodge rates and resistances explode out of fucking nowhere and if you're not stacking dodge and accuracy on your characters you're going to be repeatedly missing your attacks while enemies land critical hits on you back to back. Then not only do you have to grind out more high level characters to replace the ones you lose but you'll also need to grind out new items since you were probably farming for bonus damage and sanity reduction before and don't have any really good dodge/accuracy items.
Basically, resistance and accuracy trinkets are kind of pointless early to mid game because you can stack damage through veteran dungeons without much issue, but if you don't have good accuracy/dodge/resistance items and quirks by level 5 you're going to get screwed because all of a sudden those stats become king.