The cursed eye is the most obnoxious item to pick up, I got achievements for beating two levels/areas twice without getting hit but not the character unlock, and mom's leg comes down too fast while the shadows don't seem noticeable enough in general. I also dislike when you get a lot of stuff following you around because it's just too much in the later levels.
Great game, just frustrated after my first two runs were a success and then I keep getting shitty RNG the subsequent ones. The walls spiders that shoot beams are also cheap as fuck.