Hm. Well we did enjoy the shit out of Tekken on the consoles back in the day. Nothing like drunk and high random buttonsmashing to determine the real champion in the room. Theres also GTA as mentioned before. Also Far Cry 2. You can make random maps fast there and play em instantly, so you can make and play em basically at an instant without waiting and while being drunk/high. When i did it with my pals...well the turnouts were....interesting, to say the least. Also definately get 4 drunk/high buddies together and play SWAT4. Jesus fucking christ is that awesome when your entire tactical team is basically close to passing out infront of the PC and just dicking around. We tased a defenceless old lady and shot eachother with paintballguns. We, the policedepartments finest! Definately try it.
Kinda wierd that someone mentioned LoL here. Cause it really is the complete opposite. It is definately for sober guys. MOBAs are very bad when you are looking to just mess around.